Struggling with alcohol or opioid dependence is tough. Vivitrol for opioid use disorder can help manage this condition. This blog post will explain how Vivitrol works, its benefits, how people taking Vivitrol can experience side effects, and what to expect during a treatment program.

Keep reading to learn more about this helpful medication!

Key Takeaways

• Reduces Cravings: Vivitrol helps reduce opioid cravings by blocking mu opioid receptors in the brain. This action prevents feelings of euphoria from opioids, making them less appealing.
• Monthly Vivitrol Injection: Vivitrol is given as a monthly injection by a healthcare provider. Each dose contains 380 mg of naltrexone and works for about 30 days.
• Effectiveness: Studies show that around 36% of people using Vivitrol stayed off opioids for 24 weeks. It can also cut heavy drinking days by 25%, helping those with both alcohol and opioid use disorders.
• Potential Side Effects: Common side effects such as nausea, fatigue, headaches, and dizziness are common. Serious risks include severe injection site reactions as well as following symptoms of liver damage.
• Financial Support: Treatment for opioid addiction can cost around $1,200 per month. Insurance may cover costs, and financial aid programs are available to help manage expenses.

What is Vivitrol?

Vivitrol is a medication used to treat opioid and alcohol use disorders. It contains the active ingredient naltrexone, which helps reduce cravings and prevent relapses.

Definition and Overview of How Vivitrol Works

Vivitrol is a brand name for naltrexone. Naltrexone is an extended-release injectable drug. The FDA first approved Vivitrol in 2006. This injectable naltrexone helps treat opioid use and alcohol dependence. Naltrexone works by blocking the effects of opioids in the brain. In the form of injectable extended-release naltrexone, it helps reduce cravings and prevents relapse after detoxification.

Active Ingredient: Naltrexone

The drug that is FDA-approved for the treatment for OUD is made up of numerous ingredients. For starters, Naltrexone is the active ingredient in Vivitrol. It works by blocking mu opioid receptors. This means it can prevent opioids from having any effect on your body via the endorphin receptors. If someone tries to use drugs like heroin or codeine, they will feel no high.

This helps people stop using opioids and avoid relapse. Naltrexone is an opioid antagonist, which also reduces cravings for opioids. Many doctors use the primary form of naltrexone for opioid addiction or dependence treatment. The use of long-acting injectable form of naltrexone is very common by medical professionals. Thanks to its capabilities, many doctors prefer naltrexone for opioid or alcohol dependence treatment. Understanding how this drug works leads us to look at its uses in treating Opioid Use Disorder (OUD).

Uses of Vivitrol in Treating Opioid Use Disorder

Vivitrol helps people who struggle with opioid addiction. It works by blocking the brain’s opioid receptors to reduce cravings and prevent relapse.

Mechanism of Action

Vivitrol works because it is an opioid antagonist. This means it blocks mu opioid receptors in the brain. When these receptors get blocked, opioids can’t create feelings of euphoria or pain relief.

This makes Vivitrol helpful for people with opioid use disorder. It stops the effects of opioids, helping individuals avoid the highs they might seek from opioids like heroin or pain relievers such as oxycodone.

Effectiveness and Clinical Benefits

Vivitrol helps people stop using opioids and alcohol. Clinical trials show that 36% of Vivitrol users stayed off opioids for 24 weeks. This medicine blocks the euphoric effects of these drugs, reducing cravings.

Vivitrol also cuts heavy drinking alcohol days by 25%. It can be a good choice for those dealing with both opioid or alcohol addiction. Many find it helpful in staying clean and sober long-term.

How is Vivitrol Administered?

Vivitrol is given as an injection once every month. A healthcare provider will give you the shot, usually in the buttocks.

Dosage Forms

Medications like Vivitrol come as a powder for suspension. It is given as an intramuscular injection. A healthcare provider will inject it into the gluteal muscle. This area is in the upper part of the buttock.

Recommended Administration Protocol

After understanding the dosage forms, it’s crucial to follow the recommended administration protocol. This ensures Vivitrol works effectively and safely.

1. A healthcare provider will inject Vivitrol.
   • Injection is done once a month.
   • The dose of Vivitrol is 380 mg.

    

2. The injection of Vivitrol goes into the muscle (intramuscular).
   • It alternates between the buttocks each month.

    

3. Ensure no opioids are in your system before starting Vivitrol.
   • Detox for at least 7-14 days prior.

    

4. Observe for any immediate side effects post-injection.
   • Stay under observation for a brief period after receiving the shot.

    

5. Schedule follow-up appointments monthly.
   • Regular visits help monitor progress and address any concerns.

    

Following these steps helps manage opioid use disorder effectively with Vivitrol.

Key Benefits of Vivitrol

Vivitrol helps people reduce their cravings for opioids. It also blocks the effects of opioid drugs in the body.

Reduces Cravings

Vivitrol blocks the euphoric effects of opioids. This action helps to reduce cravings for these drugs. Many users find it easier to stay opioid-free while on Vivitrol.

In trials, 36% of Vivitrol users remained opioid-free for 24 weeks. Blocking the high that opioids give makes them less appealing. This plays a key role in reducing relapse risk and supporting long-term recovery.

Blocks the Effects of Opioids

Vivitrol reduces cravings and also blocks the effects of opioids. It works as an opioid antagonist by blocking mu opioid receptors in the brain. These blocked receptors stop opioids from creating their usual effects like intoxication, euphoria, and pain relief.

This medicine prevents feelings of pleasure from drug use. So it helps people stay sober. Blocking these effects is key to preventing relapse in those recovering from addiction to opioids like morphine or fentanyl.

Potential Vivitrol Side Effects

Vivitrol may cause some side effects. Some are mild, but others can be serious and need medical attention.

Common Side Effects

Nausea is a common side effect of Vivitrol. Some users also feel tired or sleepy. Headaches and dizziness are often reported too. These symptoms of Vivitrol may be mild but can still cause discomfort.

Vivitrol can lead to stomach issues like vomiting, diarrhea, and cramps. These effects might not last long but need attention if severe. Always talk to your doctor about any side effects you experience with this medication.

Serious Side Effects

Some side effects of Naltrexone or Vivitrol can be severe. One risk for people who use Vivitrol is an opioid overdose due to increased sensitivity to opioids after stopping the treatment of opioid use disorder. This means that if someone uses opioids again, they might need much less to overdose.

Severe injection site reactions can occur, which sometimes need surgery. Also, liver damage or hepatitis can develop. Regular monitoring by a healthcare provider is essential for safety reasons.

Precautions and Warnings

Some people should not use Vivitrol. It can cause severe allergic reactions or liver damage in certain individuals.

Who Should Not Use Vivitrol

Vivitrol is not for everyone. Some people should avoid this medication due to health risks.

1. Currently Using or Dependent on Opioids: Vivitrol is dangerous for those currently using opioids or dependent on them. It can cause severe symptoms of opioid withdrawal.
2. Recent Opioid Use: People must be opioid-free for at least 7 to 14 days before starting Vivitrol to prevent withdrawal effects.
3. Liver Disease: Those with active liver disease should not use Vivitrol, as it can worsen liver function.
4. Allergic Reactions: Anyone who has had an allergic reaction to naltrexone or any other ingredients in Vivitrol should avoid it.
5. Pregnant or Breastfeeding Women: Pregnant and breastfeeding women should not use Vivitrol, as it may harm the baby.
6. Mental Health Issues: People with a history of depression or suicidal thoughts need careful assessment before using Vivitrol, as the drug may exacerbate these conditions.
7. Patients under 18 Years Old: The safety and effectiveness of Vivitrol in children have not been established, so it is not recommended for anyone under 18 years old.
8. Other Medications Interaction: Those taking opioid analgesics like methadone or other medications such as Xanax should consult their doctor before starting Vivitrol due to potential drug interactions.
9. Severe Allergic Reaction History: Individuals with a known history of severe allergic reactions to similar medications should avoid using Vivitrol.
10. Naltrexone Sensitivity: Anyone with sensitivity to naltrexone should steer clear of this treatment option.

These points list the primary concerns for avoiding Vivitrol therapy based on scientific data and medical recommendations.

Important Safety Information

People with liver problems or bleeding disorders need to inform their doctors before taking Vivitrol. Immediate medical attention is required for symptoms of overdose.

Allergic reactions to naltrexone, a key ingredient in Vivitrol, are serious and should be reported right away. Watch for signs and report side effects such as trouble breathing, severe dizziness, or yellowing of the skin.

Vivitrol and Other Treatments

Vivitrol is often compared to other treatments like Sublocade and Suboxone. Each has different strengths and can be used together with therapy for best results.

Comparison with Other Medications (Sublocade, Suboxone)

When comparing Vivitrol to other medications like Sublocade and Suboxone for treating opioid use disorder, the differences in their formulation, administration, and effectiveness are important to consider.

Medication	Active Ingredient	Administration Method	Duration of Effect	Mechanism of Action	Common Side Effects
Vivitrol	Naltrexone	Monthly Injection	30 days	Opioid Antagonist	Nausea, Fatigue, Headache
Sublocade	Buprenorphine	Monthly Injection	30 days	Partial Opioid Agonist	Constipation, Nausea, Headache
Suboxone	Buprenorphine/Naloxone	Daily Sublingual Film/Tablets	24 hours	Partial Opioid Agonist/Antagonist	Constipation, Insomnia, Dry Mouth

Use with Other Treatments

Vivitrol can be used with other treatments like counseling and support groups. Combining these treatments can provide the best results. Counseling helps address mental health issues, while Vivitrol reduces cravings and blocks opioid effects.

Some people compare Vivitrol with other medications like Sublocade and Suboxone. Each medication works differently, but all aim to prevent relapse and help manage opioid use disorders.

Consult your healthcare provider about the best treatment plan for you. Always inform them about any other medications you’re taking.

Managing Side Effects and Risks

Monitor and manage common side effects closely. Take action if severe reactions occur.

Monitoring and Managing Common Side Effects

Monitoring and managing common side effects of Vivitrol is important. This helps ensure patient safety during treatment.

1. Nausea: Many patients may feel nauseous. Eating small meals can help.
2. Headache: Some may experience headaches. Drinking water and resting can reduce pain.
3. Dizziness: Dizziness can occur, especially after the injection. Avoid driving if feeling dizzy.
4. Fatigue: Patients might feel very tired at first. Resting often aids in recovery.
5. Injection Site Reactions: Redness or pain at the injection site is common. Using a cold pack can ease discomfort.
6. Liver Damage: Vivitrol can affect liver enzymes. Regular blood tests are needed to check liver health.
7. Insomnia: Trouble sleeping can happen to some people. Creating a bedtime routine may improve sleep quality.
8. Decreased Appetite: Appetite loss is possible with Vivitrol use, leading to weight loss in some cases.
9. Anxiety: Anxiety levels might increase for some individuals, requiring regular mental health check-ups.
10. Depression: Feelings of depression should be monitored closely and reported to a doctor immediately if severe.
11. Fever and Chills: A slight fever or chills can occur post-injection but usually pass quickly.
12. Muscle Cramps: Muscle cramps might need gentle stretches and increased fluid intake for relief.
13. In case of severe reactions like allergic responses or breathing problems, seek emergency medical help immediately.

Maintaining open communication with your healthcare provider will ensure proper management of these side effects during the course of Vivitrol treatment.

What to Do in Case of Severe Reactions

Severe side effects from Vivitrol need fast action. They may require medical help right away.

1. Painful Injection Site: Severe reactions at the injection site, like intense pain or swelling, can happen. Surgery may be needed to treat these issues.
2. Allergic Reactions: Look for signs like itching, rash, or trouble breathing. Call 911 immediately if you notice these symptoms.
3. Liver Damage: Signs include yellowing of the skin or eyes, dark urine, and upper belly pain. Stop taking Vivitrol and contact your doctor right away.
4. Depression and Suicidal Thoughts: Watch for mood changes or thoughts of self-harm. Seek medical attention immediately if you experience this.
5. Overdose Symptoms: These include confusion and slowed breathing (difficulty breathing). Go to the emergency room or call 911 without delay.
6. Severe Headaches: If a headache lasts long or feels different from usual headaches, contact your healthcare provider soon.
7. Rapid Heartbeat: A fast or irregular heartbeat needs immediate attention from a healthcare professional.
8. Symptoms Not Improving: If any severe reactions do not improve or worsen, seek medical help right away to prevent further complications.

If you are experiencing opioid withdrawal symptoms, make sure to inform your doctor and follow their advice closely to manage these severe reactions effectively. If advised, stop Vivitrol consumption.

Frequently Asked Questions

People often ask how fast Vivitrol starts working. Another common question is whether Vivitrol is a controlled substance.

How Long Does Vivitrol Take to Work?

Vivitrol starts working the day it is injected. This means you can feel its effects almost right away. The medication helps block the euphoria from opioids, making them less appealing.

The effects of Vivitrol last for one month. It remains in your body for about 30 days and cannot be removed during this time. Regular monthly injections help keep cravings in check and support long-term recovery from opioid addiction.

Is Vivitrol a Controlled Substance?

Vivitrol is not a controlled substance. Its active ingredient, Naltrexone, blocks opioid effects in the brain. This makes it different from drugs like Suboxone or Methadone, which are controlled substances due to their potential for abuse.

Doctors use Vivitrol to help people with opioid use disorder. It reduces cravings and helps prevent relapse. Since it’s not addictive and has no abuse liability, Vivitrol offers a safer option for patients battling addiction.

Financial and Insurance Assistance

Treatment with Vivitrol can be costly. Many insurance plans and financial support programs can help cover expenses.

Cost of Treatment

Vivitrol treatment can be expensive. The price may vary, but it often costs around $1,200 per monthly injection. This cost does not include doctor visits or lab tests.

Insurance can cover the cost for many people. Providers like Aetna, Anthem, Cigna, Medicare, and United Healthcare may help pay for Vivitrol. Financial support programs are also available to assist those in need.

Available Financial Support Programs

The cost of Vivitrol treatment can be high. Fortunately, there are several financial support programs to help patients.

1. Insurance Coverage: Many insurance plans cover Vivitrol. Patients should check with their insurers to understand what is covered.
2. Patient Assistance Programs: The manufacturer of Vivitrol offers assistance programs. These programs help reduce out-of-pocket costs for eligible patients.
3. Nonprofit Organizations: Some nonprofits provide financial aid for substance abuse treatment. Patients can seek help from these organizations for covering Vivitrol costs.
4. Government Programs: Medicaid and other government aids may also cover Vivitrol treatment. It is important to verify eligibility and coverage details.
5. Healthcare Provider Support: Healthcare providers and treatment centers often have information on available resources. They can guide patients on how to apply for financial aid.
6. Proactive Communication: Patients should communicate their financial concerns with healthcare providers early on. This helps in finding suitable support options without delay.

Seeking and securing financial assistance ensures that more people receive the help they need with opioid use disorder treatment using Vivitrol.

Conclusion

Vivitrol can help those with opioid use disorder. It reduces cravings and blocks the effects of opioids. This medication is an important part of a treatment program. Always consult medical professionals at an addiction treatment center about any concerns and follow their guidance closely.

FAQs

1. What is Vivitrol and how does it help with opioid use disorder?

Vivitrol is a prescription medication used to treat opioid use disorder. It acts as an opiate antagonist, blocking the effects of opioids and helping prevent relapse.

2. Can Vivitrol be used during opioid detoxification?

Yes, but it should only be administered after completing detoxification to avoid causing severe opioid withdrawal symptoms.

3. Are there any side effects of using Vivitrol for alcohol or opioid addiction treatment?

Common side effects include sleeplessness, bruising at the injection site, weight gain, and sometimes increased alanine aminotransferase levels in blood tests.

4. Is it safe to take other medications while on Vivitrol?

You should consult your doctor before combining Vivitrol with other drugs like central nervous system depressants (e.g., alprazolam), pain medications (e.g., acetaminophen), or stimulant medications (e.g., amphetamine/dextroamphetamine).

5. How does Vivitrol compare to other treatments like Narcan or Suboxone for preventing relapse?

While Narcan treats opioid overdoses and Suboxone helps reduce cravings during recovery, Vivitrol works by blocking opioid receptors completely without causing physical dependence.

6. Can breastfeeding mothers use Vivitrol safely?

Breastfeeding mothers should discuss with their healthcare provider since small amounts of Vivitrol passes into breast milk; however, its safety profile may vary depending on individual circumstances related to substance use disorders or mental health treatment needs.